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Nitric oxide (NO) is a free radical species that diffuses and concentrates in the hydrophobic core of low-density lipoprotein (LDL) to serve as a potent antioxidant. Peroxynitrite, the product of the diffusion-limited reaction between NO and superoxide anion, as well as lipoxygenase, represent relevant mediators of oxidative modifications in LDL. The focus of this review is the analysis of interactions...
This article reviews our current understanding of the mechanisms of low-density lipoprotein (LDL) oxidation and the potential role of oxidized lipoproteins in atherosclerosis. Studies in hypercholesterolemic animal models indicate that oxidation of LDL is likely to play an important role in atherogenesis. Epidemiological investigations further suggest that the dietary intake of antioxidants is inversely...
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