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Background and aims
Existing assessments of the time‐trends of opioid‐related mortality, hospitalization and emergency department visits in Canada have relied mainly on provincial databases, while national assessments generally do not provide information before 2016. We aimed to estimate Canadian national time trends in opioid‐related mortality from 2000 to 2017 and opioid‐related hospitalization...
The instrumental variable (IV) method can remove bias because of unobserved confounding, but it is unclear to what extent the choice of the IV may affect the results. We compared the estimates obtained with different provider-based IVs in a real-life observational comparative drug effectiveness study.We assessed the effectiveness of rhythm vs. rate control treatment in reducing 5-years mortality in...
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