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Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued relapse. Studies show that brain oxidative stress is consistently associated with alcohol‐induced neuroinflammation, and literature implies that oxidative stress and neuroinflammation perpetuate each other. In line with a self‐perpetuating mechanism, it is hypothesized...
Objective
To estimate the effect of early administration of aspirin on the prevention of pre‐eclampsia in high‐risk women.
Methods
This was planned as a randomized, double‐blind, placebo‐controlled trial of aspirin for women with risk factors for pre‐eclampsia. Participants were randomized to start either aspirin (81 mg/day) or placebo at 11 + 0 to 13 + 6 weeks of gestation. The primary outcome...
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