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Genetic absence epilepsy rats from Strasbourg are a strain of Wistar rats in which all animals exhibit spontaneous occurrences of spike and wave discharges (SWDs) in the EEG. In this paper, we propose a novel method for the detection of SWDs, based on the key observation that SWDs are quasi-periodic signals. The method consists of the following steps: 1) calculation of the spectrogram; 2) estimation...
To explore the difference of gene expression in rat mesenchymal stem cell (MSC) and in the hippocampus of the Alzheimerpsilas disease (AD) model rats on Natural Brain-Kinetine by Gene chips. Methods: Rat MSC is primary cultured according to method-routie. The MSCs have two groups, the control group and treatment group without or with Natural Brain-Kinetine (NBK) respectively. MSCs gene expression...
We examined Sprague-Dawley rat liver tissue and primary hepatocyte cells to understand how they compared in gene expression responses to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Gene expression was analyzed in primary cell cultures exposed to 7.5, 15, or 30 mg/L RDX for 24 and 48 hours. Cells were compared to liver from rats 24 hours after exposure to 12, 24, or 48 mg/Kg RDX. Similarity of present/absent...
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