The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach...
Optical imaging is unequivocally the most versatile and widely used visualization modality in clinical practice and life sciences research. In recent years, advances in photonic technologies and image formation methods have received particular attention in biological research and the drug discovery process for non-invasively revealing information on the molecular basis of disease and treatment. An...
Fluorescence molecular tomography has become a promising technique for in vivo small animal imaging and has many potential applications. Due to the ill-posed and the ill-conditioned nature of the problem, Tikhonov regularization is generally adopted to stabilize the solution. However, the result is usually over-smoothed. In this letter, the third-order simplified spherical harmonics approximation...
Because of the remarkable ability of cancer cells to adapt and survive, finding effective treatments against cancer depends upon identifying and attacking targets and pathways critically important for the cancer cell. The tumor physiological microenvironment, interactions between cancer cells and stromal cells such as endothelial cells, fibroblasts and macrophages, the extracellular matrix, and a...
Fluorescence mediated tomography allows quantitative, three-dimensional imaging of optical reporter probes in whole animals and is therefore emerging as a powerful molecular imaging tool. The achievable image quality in fluorescence tomography is limited by the high-degree of light scatter in biological tissue. Time-gated detection of early-arriving and therefore minimally-scattered photons transmitted...
Fluorescence tomography has become increasingly popular for detecting molecular targets for imaging gene expression and other cellular processes in vivo in small animal studies. In this imaging modality, multiple sets of data are acquired by illuminating the animal surface with different excitation patterns, each of which produces a distinct spatial pattern of fluorescence. This work addresses one...
Over the past decade near infrared spectroscopy (NIRS) and imaging are rapidly evolving for a large number of new clinical applications. These techniques, based upon near-infrared light transmission through biological tissues, aim to monitor the hemoglobin and myoglobin concentration changes due to particular physiological state. Clinical applications regard, for instance, the monitoring of muscles...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.