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The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and concentrations of malondialdehyde (MAD) in serum, spleen and bursa of Fabricius and the concentrations of Immunoglobulin G (IgG) , Immunoglobulin A (IgA), Immunoglobulin M (IgM) and HI antibody titer to Newcastle Disease in serum were detected in chickens with different levels sub-chronic aluminum (Al) intoxication produced...
The purpose of this paper was to find some feature pattern which may be used in diagnosis of blood stasis syndrome (BSS, a unique concept of traditional Chinese medicine) with myocardial ischemia. After establishing an animal model of Chinese experimental miniature swine, 7 indicators in plasma, e.g. troponin T (cTNT), heat shock protein 27 (HSP27), cytochrome C (Cyt C), endothelin-1 (ET-1), calcitonin...
The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach...
Optical imaging is unequivocally the most versatile and widely used visualization modality in clinical practice and life sciences research. In recent years, advances in photonic technologies and image formation methods have received particular attention in biological research and the drug discovery process for non-invasively revealing information on the molecular basis of disease and treatment. An...
Because of the remarkable ability of cancer cells to adapt and survive, finding effective treatments against cancer depends upon identifying and attacking targets and pathways critically important for the cancer cell. The tumor physiological microenvironment, interactions between cancer cells and stromal cells such as endothelial cells, fibroblasts and macrophages, the extracellular matrix, and a...
Objective: By analyzing the effect of natural cerebrolysin (NC) on gene expression profile of rat hippocampus Alzheimer's disease (AD), to explore its molecular genetic pharmacodynamic mechanism of anti-AD. Methods: The experiment included the AD model, sham-operation and NC treated group. The changes of hippocampus gene expression profiles in the above three groups were analyzed by Affymetrix rat...
Chemical medicines and antibiotics can kill pathogenic microorganisms in aquiculture animals, but they will lead to environmental pollution and serious food safety problems. Therefore, study on the selection for the disease resistant group of animals is necessary to solve the problem and promote the development of aquaculture. From the view of the relationship between fishes and pathogenic microorganisms,...
The newly-developed blood immunological reaction pathway diagram experiment system has been used in a series of studies on the role of erythrocytes in regulating the immunological reactions of lymphocytes, and it has been found that when the tumor antigen S180 is activated, erythrocytes can increase the expression of CD25 on the surfaces of the surrounding hemolymphocytes, which indicates the immunological...
Diagnostic ultrasound imaging can be used to acquire multidimensional datasets of the presence of specific molecules playing a role in disease progression. This imaging technique relies on the sensitive detection of targeted ultrasound contrast agents (UCAs) which consist of encapsulated gas bubbles with several micrometers diameter and functionalized surfaces. They can be detected by their nonlinear...
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