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We have previously shown that peroxisome proliferator-activated receptor-γ (PPARγ) agonists inhibited the inflammatory response of RSV-infected human lung epithelial cells. In this study, we supply evidence that specific PPARγ agonists (15d-PGJ 2 , ciglitazone, troglitazone, Fmoc-Leu) efficiently blocked the RSV-induced cytotoxicity and development of syncytia in tissue culture (A549, HEp-2)...
The data we present here suggest that agonists of peroxisome proliferator-activated receptor-γ (PPARγ) can attenuate the effects of beta-amyloid peptide (Aβ). Alzheimer's disease is associated with elevated levels of Aβ, and enhanced expression of PPARγ. In this study, we determined that application of Aβ [1–40] could impair hippocampal post-tetanic potentiation (PTP) and long-term potentiation...
In this study, we examined the signaling pathways for extracellular signal-related protein kinase (ERK) activation by three structurally different peroxisome proliferator activated receptor-γ (PPARγ) agonists. In murine C2C12 myoblasts, treatment with 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), ciglitazone, and GW1929 leads to ERK1/2 phosphorylation in a time- and concentration-dependent manner....
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