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Impairments in cognitive performance have been observed in aged apolipoprotein E (apoE)-deficient mice, and apoE 4 allele is a risk factor in Alzheimer's disease (AD). The absence of apoE correlates with diminished antioxidative capacity in animals, and elevated cerebral oxidative stress has been observed in AD individuals carrying the 4 alleles. Nitric oxide (NO) is a neurosignaling molecule...
β-Amyloid protein (A β) is the major component of the senile plaques in Alzheimer's disease (AD), and microglial cells have been shown to be closely associated with these plaques. However, the roles of A β and microglial cells in pathogenesis of AD remain unclear. Incubation of rat microglial cells with A β(1-40) caused a significant increase in nitrite, a stable metabolite of nitric oxide (NO),...
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