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[Phe 1 Ψ(CH 2 -NH)Gly 2 ]-nociceptin-(1-13)NH 2 is an nociceptin analogue which has been shown to be a selective antagonist of the nociceptin receptor in peripheral tissues. We now report that intrathecal [Phe1Ψ(CH 2 -NH)Gly 2 ]-nociceptin-(1-13)NH 2 produced a dose-dependent depress ion of the nociceptive flexor reflex in rats. an effect that...
We have examined the effects of intrathecal (i.t.) human calcitonin gene-related peptide (hCGRP) and its C-terminal fragment hCGRP(8-37), a proposed CGRP antagonist, on the flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. hCGRP at 26 pmol caused a moderate facilitation of the reflex which was not antagonized by hCGRP(8-37) at doses ranging from 26 pmol to 5.2 nmol. Furthermore,...
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