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Push-pull perfusions of the anterior hypothalamus were performed in four groups of guinea pigs characterized as follows: (a) hypothalamus perfused with artificial cerebrospinal fluid (CSF), intramuscular (im) injection of 20<space>μg/kg bacterial lipopolysaccharide (LPS); (b) hypothalamus perfused with CSF, im injection of saline; (c) hypothalamus perfused with CSF which contained 0.1<space>μg/μl...
Tumor necrosis factor double receptor-knockout (TNFR KO) mice lacking functional genes for the TNF p55 and p75 receptors show exacerbated febrile responses to endotoxin. TNFR KO mice and wild-type (WT) control animals were intraperitoneally treated with 2.5<space>mg/kg of lipopolysaccharide (LPS), and the effect of this treatment on plasma levels of TNF, interleukin (IL)-6, IL-10 and IL-1 type...
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