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A small series of histamine H 3 receptor (H 3 R) ligands (1–5) incorporating different antiepileptic structural motifs has been newly synthesized. All compounds exhibited moderate to high in vitro hH 3 R affinities up to a sub-nanomolar concentration range with pK i values in the range of 6.25–9.62 with varying preferences for this receptor subtype. The compounds (1–5)...
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