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We have recently shown that adenosine-triphosphate-sensitive potassium [K+(ATP)] channel protein subunit, Kir6.1 is a phosphospecific interaction partner of the gap-junction protein connexin43 (Cx43). Since, both Cx43 and K+(ATP) are known to be involved in cell survival during hypoxia, we addressed the question, whether the interaction between Cx43 and K+(ATP) has a role in protecting cell against...
Hypoxic/ischemic condition induces neuronal apoptotic events, which consequently lead to neuronal cell death. However, its specific mechanistic pathways remain obscure. Cobalt chloride (CoCl 2 ) could mimic the hypoxic condition including the production of reactive oxygen species (ROS). In this report, we investigated the signal pathway of CoCl 2 -induced apoptosis in PC12 cells. The...
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