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Mycobacterium avium subsp. paratuberculosis (MAP), the agent of paratuberculosis, is a slow growing mycobacteria that survives within ruminant mononuclear phagocytes by preventing cell activation and phagosome maturation. We investigated interactions between MAP and monocyte membrane receptors that result in activation of the mitogen-activated protein kinase (MAPK) p38 pathway and suppression of monocyte...
We compared the kinetics of activation and antimicrobial activities of MAPK-p38 and MAPK-ERK in bovine monocytes infected with Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium avium subsp. avium (Maa). Monocytes were incubated with MAP or Maa organisms with or without a specific inhibitor of the MAPK-p38 pathway (SB203580), and MAPK phosphorylation and antimicrobial functions of...
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