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Sublethal ischemia or hypoxia triggers adaptive changes that protect the brain against future hypoxic/ischemic damage. Preexposure of in vitro hippocampal slices to brief periods of hypoxia increases the resistance of Schaffer collateral-CA1 synaptic potentials to further, longer periods of hypoxia that would otherwise cause an irreversible loss of synaptic transmission. Since hypoxia has been shown...
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