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Reward-predictive cues are important to guide behavioral responding. In a series of experiments, we sought to characterize the role of dopamine in the dorsomedial striatum in modulation of reward-directed responding by visual cues. Different groups of rats subjected to infusion of 6-hydroxydopamine or vehicle into the posterior part of the dorsomedial striatum (pDMS) were tested in three experiments...
The acoustic startle response is enhanced during states of fear and attenuated during pleasant ones. Our question was whether pharmacological stimulation of the reward system disrupts the learning and retrieval of conditioned fear as measured by fear-potentiated startle. We therefore injected the dopamine agonist amphetamine into the nucleus accumbens (NAC) immediately before either acquisition or...
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