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Duchenne muscular dystrophy (DMD) is a devastating and ultimately fatal disease characterized by progressive muscle wasting and weakness. DMD is caused by the absence of a functional dystrophin protein, which in turn leads to reduced expression and mislocalization of dystrophin-associated proteins including neuronal nitric oxide (NO) synthase mu (nNOSμ). Disruption of nNOSμ signaling results in muscle...
As mediators of relaxation of vascular smooth muscle, cGMP and cAMP signaling pathways have become an important focus of drug development for pulmonary hypertension. Phosphodiesterases (PDEs), the enzymes that catalyze hydrolytic cleavage of the 3’-phosphodiester bond of the cyclic nucleotides, controlling intracellular levels, are obvious drug targets. PDEs have a wide distribution in normal tissues...
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