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The objective of the study was to determine the in vivo role of Filamin A (FLNA) in osteoclast generation and function, through the assessment of trabecular bone morphology, bone turnover, and the resulting changes in mechanical properties of the skeleton in mice with targeted deletion of FLNA in pre-osteoclasts. Using a conditional targeted knockdown of FLNA in osteoclasts, we assessed bone characteristics...
Summary We found that age-related decline in bone mineral density (BMD) is more pronounced in women than in men, that lean mass was the most important determinant of BMD in all age groups in both sexes, and that different factors may be important for bone health of men and women and at different ages. Introduction Multiple factors may affect bone mineral density (BMD). Our objective was...
To investigate aging bone structure of humans—here, in the lumbar vertebral bodies—requires methodologies that have sufficiently high resolving power yet still have sufficient width and depth of field. No clinical imaging method can come close to meeting the first requirement, leading to the disadvantage of being limited to postmortem studies. Few microscopic methods meet the second and third requisites...
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