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We investigated the effect of HER2 overexpression on resistance to aromatase inhibitor letrozole in MCF-7 breast cancer cells stably expressing cellular aromatase (MCF-7/CA). Forced expression of HER2 in MCF-7/CA cells by infection with retroviral vector showed increased Akt and MAPK phosphorylation and phosphorylation of estrogen receptor (ER) a. on Ser118 and Serl67. MCF-7/CA cells overexpressing...
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