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Neurons, unlike glia and most other cell types, fail to express major histocompatibility complex (MHC) molecules, even in response to IFNγ. This study shows that sensory neurons but not glia constitutively express high levels of suppressor of cytokine signaling-1 (SOCS1), a negative regulator of IFNγ signaling. Neurons from SOCS1 null mice expressed class I MHC in response to IFNγ, while SOCS1 overexpression...
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