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Introduction of the yellow obese gene (A y ) into mice (KKAy) results in obesity and diabetes by 5 weeks of age.Using this model of type 2 diabetes, we evaluated male and female 6- to 8-month-old wild-type (WT, n=10) and KKAy (n=22) mice subjected to myocardial infarction (MI) and sacrificed at day (d) 7.Despite similar infarct sizes (50%±4% for WT and 49%±2% for KKAy, P=not significant),...
Circulating interleukin-6 (IL-6) is increased in diabetes patients who are in general also at greater cardiovascular risk. Thus, we investigated whether IL-6 is associated with incident primary cardiovascular events and improves risk prediction in diabetes patients.Serum IL-6 levels were measured at baseline in 1072 diabetic participants of the ESTHER study. During 5years of follow-up, 84 experienced...
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