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Rationale Nitric oxide (NO) is implicated in the acute locomotor activating effects of some addictive drugs such as amphetamine, caffeine, and PCP, but has not been investigated in the case of toluene. Objectives This study determined the contribution of the NO-cyclic GMP (cGMP) pathway to locomotor stimulant effects of toluene. Methods Locomotor activity was measured for 90 min immediately following...
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