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The liver lobule is formed by hepatocytes and cholangiocytes, constituting the two hepatic epithelial cell populations, as well as by cells that are collectively defined as nonparenchymal cells (1–4). Morphometric and functional analyses indicate that hepatocytes occupy almost 80% of the total liver volume and perform the majority of liver functions.
Initiation and progression of hepatocellular carcinoma (HCC) is intimately associated with a chronically diseased liver tissue. This diseased liver tissue background is a drastically different microenvironment from the healthy liver, especially with regard to immune cell prevalence and presence of mediators of immune function. To better understand the consequences of liver disease on tumor...
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