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Host cell factor‐1 (HCF‐1) is a conserved regulator of the longevity and stress response functions of DAF‐16/FOXO. SKN‐1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro‐longevity factor. Here, we demonstrate that SKN‐1 contributes to the enhanced oxidative stress resistance incurred by hcf‐1 mutation in C. elegans. HCF‐1 prevents the nuclear accumulation of...
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