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The mitochondrial genome has been proposed as aprincipal site of somatic mutation during ageing. Avariation of the error catastrophe model has beenproposed, in which ROS damages the mitochondrialgenome, which leads to additional ROS production in apositive feed back cycle. This leads to major DNAdamage, bioenergy crisis, and reduced functionalcapacity in old age and contributes to mortality.Therefore...
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