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This physiological cell death, also known as programmed cell death, takes place during the entire growth period of an organism. In general, somatic cell apoptosis can be induced through extrinsic mechanisms acting at the plasma membrane, mitochondrial or nuclear levels. Recent studies have demonstrated that apoptosis is an underlying mechanism of germ cell death during normal spermatogenesis and that...
Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential...
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