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Alzheimer’s disease (AD) is a well-described neurological disorder characterized by the presence of a number of biological processes. Deposition of β-amyloid plaques in brain, one of the main features of AD pathology, was successfully modeled in the middle of the 1990s by a generation of the β-amyloid precursor protein (APP) transgenic mouse lines. The Thy1-APP751SL transgenic line, one of this “new...
Oxidative stress and nitrosative stress have been reported to play important roles in the pathogenesis of a number of diseases including neurodegenerative diseases, cancer, ischemia, etc. Reactive nitrogen species are highly reactive and unstable. One of the best ways to quantify the amount of nitrosative stress is to measure the levels of 3-nitrotyrosine level. In addition, by using proteomics selective...
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