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Protection from colon cancer by vitamin D can be traced to the role of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D] in controlling proliferation, differentiation, and apoptosis of colonic epithelial cells. Human colonocytes express the CYP27B1-encoded 25(OH)D-1α-hydroxylase and therefore are able to convert 25-hydroxyvitamin D[25(OH)D] to 1,25(OH)2D. In vitamin D insufficiency, availability of 25(OH)D is...
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