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In this chapter, we use the term “plasminogen system” to designate the pathway that controls the conversion of plasminogen to plasmin and the proximal consequences of plasminogen activation. The “plasminogen system” is synonymous with the “fibrinolytic system,” a nomenclature that emphasizes the primary substrate of plasmin, fibrin, and function, and the outcome of fibrin degradation, fibrinolysis...
There is compelling evidence for increased neovascularization of blood vessel walls at sites of intimal hyperplasia in models of arterial stenting, angioplasty, and venous bypass graft failure. We have shown that activation of the P2Y2 nucleotide receptor (P2Y2R) in vascular endothelial cells in vitro induces VCAM-1 (vascular cell adhesion molecule-1) expression and promotes the adherence of monocytes...
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