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The neuroprotective properties of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) place these peptides in a special category of ligands that have implications for our understanding of pathological conditions as well as a potential basis for therapeutic intervention. It is remarkable that these peptides have a protective impact against such a wide...
Signal transduction mechanisms of group II metabotropic glutamate receptors (mGlu 2/3 ) remains a matter of some controversy, therefore we sought to gain new insights into its regulation by studying cAMP production in cultured neurons and astrocytes, and by examining inter-relationships of mGlu 2/3 -induced signalling with cellular calcium and various signalling...
Aggregated β/A4-amyloid is known to increase intraneuronal calcium by various mechanisms and to lead eventually to the death of the cultured neuron. This study deals with the role of β/A4-amyloid and several of its fragments in calcium homeostasis, glial fibrillary acid protein and S100β staining, morphology and survival of cultured rat hippocampal astrocytes as determined by Fura imaging, indirect...
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