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Epigenetic regulators are one of the most commonly mutated classes of genes in cancer. During cancer initiation, mutated epigenetic regulators lead to oncogenic cellular reprogramming and promote the acquisition of uncontrolled self-renewal. The emergence of CSCs requires elaborate reorganization of the epigenome.During cancer growth, epigenetic mechanisms integrate the effect of cell-intrinsic (i...
Le cancer est une maladie aux étiologies multiples, aux stades évolutifs extrêmement variés, qui présente une composante génétique dominante. Un grand nombre de gènes qui ont une influence critique pour déterminer la croissance cellulaire, la différenciation, la plasticité métabolique et la mort par apoptose se trouvent altérés de manière irréversible en cas de cancer et, de ce fait, acquièrent une...
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