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In the tumor microenvironment, the primary tumor cells may recruit and interact with stromal cells and inflammatory cells including macrophages, mast cells and neutrophiles. A great multitude of growth factors, cytokines, chemokines and growth/motility factors may be secreted by aforementioned cells in the microenvironment to trigger epithelial-mesenchymal transition (EMT), migration and invasion...
The signal transductions mediating each stage of tumor metastasis are gradually unraveled. A lot of growth factors and cytokines secreted in the tumor environment may trigger epithelial–mesenchymal transition (EMT), migration and invasion of the primary tumor via integration of multiple pathways. Further, TGF-β1/Smad signaling may switch the tumor cell from cohesive to single cell movement that facilitates...
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