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Hepatocellular carcinoma (HCC) is the most common form of liver cancer and has a poor prognosis and a low survival rate; its incidence is on the rise. Hepatitis B virus (HBV) infection is one of the main causes of HCC. A high prevalence of pre‐S deletions of HBV surface antigen, which encompass T‐cell and/or B‐cell epitopes, is found in HBV carriers; antiviral therapy and viral immune escape may cause...
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