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Background
Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial hypercholesterolaemia may serve as a human model to investigate the effect of elevated low‐density lipoprotein (LDL)‐cholesterol.
Objectives
We aimed to study the immunological...
Scope
Some studies suggest that a high dietary intake of omega‐6 fatty acids is pro‐inflammatory. However, whether omega‐6 fatty acids actually cause pathogenic inflammation in humans is debated. Therefore, the associations between expression of immunology‐related genes in peripheral blood mononuclear cells (PBMCs) and serum total omega‐6 PUFA status are investigated.
Methods and results
Serum...
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