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BackgroundInflammation leads to transcriptional downregulation of many hepatic genes, particulary those activated by retinoid X receptor‐α (RXRα) heterodimers. Inflammation‐mediated reduction of nuclear RXRα levels is a main factor in reduced nuclear receptor (NR)‐regulated hepatic gene expression, eventually leading to cholestasis and liver damage.
AimTo investigate roles for RXRα in hepatic gene...
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