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Several alterations in fibroblasts of Alzheimer's disease (AD) patients have been described, including alterations in calcium regulation, protein kinase C (PKC), and potassium (K + ) channels. Studies have also found reduced levels of the α isoform of PKC in brains and fibroblasts of AD patients. Since PKC is known to regulate ion channels, we studied K + channel activity in fibroblasts...
We have previously identified alterations of K + channel function, IP 3 -mediated calcium release, and Cp20 (a memory-associated GTP binding protein) in fibroblasts from Alzheimer's disease (AD) patients vs controls. Some of these alterations can be integrated into an index that distinguishes AD patients from controls with both high specificity and high sensitivity. We report here...
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