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This review article covers the early period of my career. I first summarize research initiated by the late Nils-Åke Hillarp, after his appointment in 1962 as professor in the Department of Histology at Karolinska Institutet. He only lived for three more years, but during this short period he started up a group of ten students who explored various aspects of the three monoamine transmitters, dopamine,...
Using in vivo microdialysis in freely moving rats, we examined the involvement of major striatal transmitters on the local modulation of the 5-HT release. Tetrodotoxin reduced the striatal 5-HT output to 15–20% of baseline. The selective 5-HT 1B receptor agonist CP 93129 (50 μM) reduced (50%) and the 5-HT 2A/2C receptor agonist DOI (1–100 μM) increased (220%) the 5-HT output. Neither...
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