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Diabetes mellitus is a major independent risk factor for acute coronary syndrome (ACS). In addition, diabetic patients with ACS suffer from increased mortality compared to their nondiabetic peers. Driven by multiple pathophysiological disturbances, such patients are predisposed to a proinflammatory, prothrombotic state, which may lead to plaque rupture. To counteract this more complex biology, several...
The status of inflammation may affect the collateral development in patients with diabetes mellitus (DM). Monocytes were found to have an important role in collateral growth in animal studies. We aimed to investigate the possible association of circulating monocyte count with collateral development in patients with DM and severe coronary artery disease (CAD). We enrolled 134 consecutive patients with...
Die Atherogenese ist ein chronischer Prozess, der schleichend und hufig Jahre vor der Manifestation eines Diabetes beginnt. In allen Stadien der Entwicklung, bis hin zur Plaqueruptur, sind Entzndungsreaktionen beteiligt. Das Ausma der Inflammation bestimmt den Verlauf der Atherogenese mageblich. C-reaktives Protein ist Ausdruck der Entzndungsreaktion, korreliert mit der Prognose und ist damit ein...
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