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Summary Cushing’s syndrome (CS) is rare during pregnancy because it is associated with infertility in approximately 71% of female patients who have the disease. The diagnosis of CS is challenging in the nonpregnant state and even more so during pregnancy for several reasons. First, pregnant women without CS develop some features of Cushing’s, such as hypertension, hyperglycemia, and striae. Second,...
The maternal hypothalamic–pituitary–adrenal (HPA) axis is up-regulated in pregnancy leading to increased serum cortisol and adrenocorticotropin (ACTH) concentrations. Placental production of corticotropin-releasing hormone and ACTH, altered pituitary responsiveness to negative feedback of cortisol, or enhanced pituitary responses to corticotropin-releasing factors may all contribute to enhanced HPA...
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