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Gene expression in Drosophila melanogaster changes significantly throughout life and some of these changes can be delayed by lowering ambient temperature and also by dietary restriction. These two interventions are known to slow the rate of aging as well as the accumulation of damage. It is unknown, however, whether gene expression changes that occur during development and early adult life make an...
The gene bak regulates apoptosis. To explore its role in the human central nervous system, we examined the distribution of its protein product, Bak, in the brains at various ages, by immunochemical and immunohistochemical means. Western blotting revealed that Bak expression in the cerebrum and cerebellum is high in the brains of the fetuses and elderly subjects, but low in those of young adults. Immunostaining...
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