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New derivatives from dehydrocrotonin (DHC, compound I), with the same anti-ulcerogenic properties but less toxicity were synthesised by reducing the cyclohexenone moiety of DHC with NaBH 4 (compound II), by reducing the cyclohexenone and lactone moieties with LiAlH 4 (compound III) and by transforming the lactone moiety into an amide (compound IV) using dimethylamine. The cytotoxicity...
The cytotoxicity of prodigiosin, an antibiotic and potential trypanocide produced by Serratia marcescens, and Benznidazole, a trypanocidal drug, were assayed on V79 fibroblast cell line. Three independent endpoints for cytotoxicity were evaluated; namely, the nucleic acid content (NAC), MTT reduction and neutral red uptake (NRU). IC 50 values of 1-20 μM were obtained for prodigiosin in...
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