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Functional neuroimaging studies have found that lateralization of activity in the dorsolateral prefrontal cortex (dlPFC) is reduced with aging. In the present study, repetitive transcranial magnetic stimulation (rTMS) was used to disrupt dlPFC activity in order to test the relationship of dlPFC laterality and age in verbal working memory (WM). Young (n=36) and older (n=35) subjects received 1Hz-rTMS...
The trail making test (TMT) is a widely applied diagnostic tool measuring executive functioning in order to discriminate between healthy and pathological aging processes. However, due to its paper-and-pencil nature it is difficult to adapt for functional brain imaging. Related neural underpinnings even in healthy aging are mostly unknown since no consistent administration for imaging is available...
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