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An essential feature of magnetic resonance (MR) probes for magnetic resonance imaging and spectroscopy is the ability to generate uniform B1+ excitation in a volume of interest. When the magnetic field strength is increased, leading to an increase in resonance frequency, the constraints on the MR probes size, the sample size and the associated radiation losses caused by conductor elements are higher...
Electrical properties tomography (EPT) holds promise for noninvasively mapping at high spatial resolution the electrical conductivity and permittivity of biological tissues in vivo using a magnetic resonance imaging (MRI) scanner. In the present study, we have developed a novel gradient-based EPT approach with greatly improved tissue boundary reconstruction and largely elevated robustness against...
Potassium-39 (K) magnetic resonance imaging (MRI) is a noninvasive technique which could potentially allow for detecting intracellular physiological variations in common human pathologies such as stroke and cancer. However, the low signal-to-noise ratio (SNR) achieved in K-MR images hampered data acquisition with sufficiently high spatial and temporal resolution in animal models so far....
We hereby propose a new method to determine the regionally passive, elastic, stress-strain relationship of the normal murine abdominal aorta in vivo. The circumferential stress-strain relationship was assessed through Laplace's law, a small deformation framework and a relationship between luminal pressure and diameter variation. The regional diameter variation of the murine abdominal aortas was obtained...
An off-resonance saturation (ORS) method was used for magnetic resonance imaging of superparamagnetic polymeric micelles (SPPM). SPPM was produced by encapsulating a cluster of magnetite nanoparticles (9.9plusmn0.4 nm in diameter) in poly(ethylene glycol)-b-poly(D, L-lactide) (PEG-PLA) copolymer micelles (micelle diameter: 60plusmn9 nm). In ORS MRI, a selective radiofrequency (RF) pulse was applied...
Chronic spinal cord compression induced cervical myelopathy is a common cause of spinal cord dysfunction. The exact mechanisms of underlying progressive cell death remain to be elucidated. In this study, in vivo diffusion tensor imaging (DTI) has been applied to investigate the microstructural changes of white matter (WM) in this neurodegenerative disease. Compared with conventional MRI techniques,...
Baseline removal by subtraction, in which each second-excitation RF pulse changes its polarity, can be successfully used in a variety of data processing applications in real time by appropriately coding the odd and even excitations. The authors demonstrate this technique in: (1) fast fat/water imaging utilizing phase modulation of the spectral components and (2) the detection of lactate in vivo by...
The safety of magnetic-resonance in vivo diagnostic procedures was the subject of a recent study by the Food and Drug Administration (FDA). The available literature on the biological effects of the static, time-varying, and RF magnetic fields was reviewed, and additional studies were carried out to address particular issues. As a result of this study, guidelines for manufacturers with regard to safety...
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