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Improvements in survival rates and the rise in the incidence of cancer, particularly in young people, has shifted the focus of treatment towards less gonadotoxic therapies, such that a larger number of survivors will remain fertile after treatment. Unfortunately, for the vast majority of cancer therapies, there is incomplete data on the extent of injury to the reproductive organs. This review uses...
As the population of childhood cancer survivors steadily increases, currently estimated at 26,000 in the UK, investigators are focusing on improving our understanding of the late side effects associated with successful cancer therapy. Long-term survivors are at risk of developing a number of late sequelae including impaired fertility, adverse pregnancy outcomes and health problems in the offspring...
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