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As virulence factors, microbial proteases often exert dual activities, enhancing the inflammatory response and affecting leukocyte functions. By activating the kallikrein-kinin system, they induce the release of kinins, which cause vascular leakage, and by inducing C5a production from the fifth complement component, they trigger the release of histamine. Leukocytes also accumulate in response to the...
Die Morbiditäts- und Mortalitätsraten der chronisch-obstruktiven Lungenerkrankung (COPD) sind heute schon erheblich und werden in naher Zukunft noch weiter ansteigen. Somit gewinnt diese Erkrankung zunehmend an volkswirtschaftlicher Bedeutung. Die Kenntnisse der zugrundeliegenden Mechanismen erscheinen daher von besonderer Relevanz, vor allem weil bislang noch keine kurativen Therapieansätze...
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