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This article is part of a Special Issue “SBN 2014”.Sex hormones are physiological factors that promote neurogenesis during embryonic and fetal development. During childhood and adulthood these hormones support the maintenance of brain structure and function via neurogenesis and the formation of dendritic spines, axons and synapses required for the capture, processing and retrieval of information (memories)...
Amyloid beta protein (Aβ) levels are elevated in the brain of Alzheimer's disease patients. Anti-Aβ antibodies can reverse the histologic and cognitive impairments in mice which overexpress Aβ. Passive immunization appears safer than vaccination and treatment of patients will likely require human rather than xenogenic antibodies. Effective treatment will likely require antibody to cross the blood–brain...
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