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Key points
Wnt ligands belonging to both canonical and non‐canonical Wnt pathways regulate membrane potential signifying a very early event in the signal transduction.
Wnts activate K+ currents by elevating intracellular Ca2+ and trigger Ca2+ release from intracellular stores.
Control of potential by Wnt ligands has significant implications for gene transcription and opens up a novel avenue to interfere...
BACKGROUNDThree prostatic cell lines, PC3, LNCaP, and DU 145, are used as established models to study cell signaling in prostate cancer. Recently, stromal cell lines of the prostate, such as P21, were also introduced. Here we investigate a basic and important mechanism of living cells: Ca2+ homeostasis in PC3, DU 145, and P21.
METHODSWe examined Ca2+ clearance mechanisms by monitoring the kinetics...
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