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BackgroundRapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2‐PD and utility as a preclinical marker has not been established.
MethodsOne hundred forty‐four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non‐manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep...
ObjectiveThe aim of the study was to examine the sense of smell in LRRK2 mutation carriers and in patients with sporadic PD (sPD).
Materials and MethodsA total of 343 individuals were included: 275 sPD of whom 90 were de novo patients with sPD, 17 LRRK2 PD, 36 healthy LRRK2 mutation carriers, and 15 healthy family members without mutation. All subjects underwent neurologic examination and olfactory...
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