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Oxidative stress in the bronchopulmonary airways can occur through a variety of inflammatory mechanisms and also following the inhalation of environmental pollutants. Oxidative stress causes cellular dysfunction and thus mammals (including humans) have developed mechanisms for detecting oxidative stress, such that defensive behavior and defensive biological mechanisms can be induced to lessen its...
Mitochondrial depolarisation has been reported to enhance the generation of superoxide anion (O ⋅−2 ) in a number of cell preparations while an inhibition has been observed with isolated mitochondria. Cerebellar granule cells equilibrated with >1 μM hydroethidine (dihydroethidium) which is oxidised to the fluorescent ethidium cation by O ⋅−2 showed a large increase in...
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