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Co‐administration of fluvoxamine (FLV) (perpetrator) and ramelteon (victim, high‐clearance CYP1A2 substrate) reportedly showed a 130‐fold increase in the area under blood‐ramelteon‐levels curve (AUCR), which is unpredictable by any method assuming the traditional well‐stirred hepatic extraction (Eh) model. Thus, in order to predict this drug interaction (DDI), a mathematical method that allows simulation...
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