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The cell surface exposure of phosphatidylserine (PS) and the plasma membrane impairment were assessed in the bone marrow of adult male Swiss mice exposed to a single 6 Gy dose of 60Co gamma-rays, and treated intraperitoneally with the aminothiol WR-2721 (Amifostine, S-2-/3-aminopropylamino/ethyl phosphorothioic acid), at a dose of 400 mg/kg body weight, 30 min prior to gamma-irradiation. The bone...
The paper presents a review of resultats concerning mechanism and kinetics of micronuclei formation. Special attention has been paid to differences in the induction of micronuclei by clastogenic compounds and spindle poisons as well as modifying factors which play important role in micronuclei formation.
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